P-Selectin Glycoprotein Ligand-1 Is Highly Expressed on Ly-6C hi Monocytes and a Major Determinant for Ly-6C hi Monocyte Recruitment to Sites of Atherosclerosis in Mice

P-Selectin Glycoprotein Ligand-1 Is Highly Expressed on Ly-6C Monocytes and a Major Determinant for Ly-6C Monocyte Recruitment to Sites of Atherosclerosis in Mice

Background—Ly-6C monocytes are key contributors to atherosclerosis in mice. However, the manner in which Ly-6C monocytes selectively accumulate in atherosclerotic lesions is largely unknown. Monocyte homing to sites of atherosclerosis is primarily initiated by rolling on Pand E-selectin expressed on endothelium. We hypothesize that P-selectin glycoprotein ligand-1 (PSGL-1), the common ligand of...

P-selectin glycoprotein ligand-1 is highly expressed on Ly-6Chi monocytes and a major determinant for Ly-6Chi monocyte recruitment to sites of atherosclerosis in mice.

BACKGROUND Ly-6C(hi) monocytes are key contributors to atherosclerosis in mice. However, the manner in which Ly-6C(hi) monocytes selectively accumulate in atherosclerotic lesions is largely unknown. Monocyte homing to sites of atherosclerosis is primarily initiated by rolling on P- and E-selectin expressed on endothelium. We hypothesize that P-selectin glycoprotein ligand-1 (PSGL-1), the common...

CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis.

Innate immune cells may regulate adaptive immunity by balancing different lineages of T cells and providing negative costimulation. In addition, CD11b(+)Gr-1(+) myeloid-derived suppressor cells have been described in tumor, parasite infection, and severe trauma models. In this study, we observe that splenic CD11b(+) cells markedly increase after experimental autoimmune encephalomyelitis (EAE) i...

Plasticity of Ly-6C(hi) myeloid cells in T cell regulation.

CD11b(+)Ly-6C(hi) cells, including inflammatory monocytes (IMCs) and inflammatory dendritic cells (IDCs), are important in infectious, autoimmune, and tumor models. However, their role in T cell regulation is controversial. In this article, we show that T cell regulation by IMCs and IDCs is determined by their activation state and is plastic during an immune response. Nonactivated IMCs and IDCs...

CD11b Ly-6C Suppressive Monocytes in Experimental Autoimmune Encephalomyelitis